NRF2 Protandim Ingredients


Protandim contains 1.8 mg of caffeine per tablet. (By comparison, a Starbuck's coffee may contain up to 150 mg. and "caffeine free" coffee may typically contain between 4-7 mg).

Microcrystalline Cellulose, Croscarmellose Sodium, Silica, Modified Cellulose, Stearic Acid, Magnesium Stearate, Maltodextrin, Medium Chain Triglycerides.

No, the blend of ingredients and their special formulation is unique to Protandim and is the subject of six US patents, one Australian patent, and one Chinese patent. The combination of ingredients creates a synergy that has been studied and different than traditional antioxidants.

No, there are no dyes or food colorings in Protandim. One of the active ingredients, curcumin, is intensely yellow.

Yes, the raw materials are tested for: pesticides/herbicides, heavy metals, active compound in Protandim's five active ingredients (for example, tests are conducted on bacopa for bacosides and Turmeric for Curcumonoids), all microbial tests and efficacy/bioavailability.

  • Ashwagandha – India
  • Bacopa – India
  • Green Tea- China
  • Milk Thistle – China
  • Tumeric – India

No, they are not "certified" organic; however, they are all harvested in their natural pure environment.

  • Withania somnifera dry root
  • Camellia sinensis dry leaf
  • Equivalent caffeine
  • Silybum marianum dry seed
  • Bacopa monnieri dry whole plant
  • Curcuma longa dry root


The raw ingredients are pressed into tablet form. Protandim tablets are pressed without any extraneous heat. The only heat that results from the process is from natural friction. There is no raw material degradation from the process. This is considered “cold” pressed or “soft” pressed.

Yes, Protandim meets or exceeds the Current Good Manufacturing Practices (“cGMPs”) for Nutritional Supplements.

All raw materials are validated before they are purchased. This means we test all inbound raw materials for quality and purity.

Also, Protandim is subject to existing dietary supplement laws, such as the Dietary Supplement Health and Education Act, including adverse event reporting requirements. LifeVantage has established the safety and purity of all its ingredients through independent laboratory testing.


No, Protandim does not contain any banned or controlled substances.  Every lot of Protandim is analyzed and certified by the Banned Substances Control Group (BSCG) to assure that Protandim does not contain any banned or controlled substances.

It's best to take Protandim with food.  Some of the active ingredients in Protandim are fat soluble. Although it is not absolutely necessary, taking Protandim with a meal containing some fat allows the ingredients to be absorbed more efficiently.

The shelf life for Protandim is three years.

No, there is no known mechanism whereby Protandim loses effectiveness over time. The formula has not been changed and bioactivity is monitored to maintain consistent potency with regard to the activation of the Nrf2 transcription factor–the mechanism by which Protandim works.

No, the ability to absorb the ingredients is self-limiting, so after a certain point no more is absorbed.

As with any supplement, particularly if you have a medical condition, are taking medication or other supplements, you should speak with your healthcare provider before taking Protandim. If you experience nausea, vomiting, diarrhea or any other difficulties after taking Protandim, discontinue taking it and consult your healthcare provider.  Do not exceed the recommended dosage of Protandim.

Some Western diets are lacking in certain nutritional elements, so multivitamin supplementation may be beneficial for some people. You can discontinue supplementing with antioxidants, however, because Protandim is more effective at eliminating free radical damage than supplementation with conventional antioxidants.

There is no expectation of any side effects for the typical Protandim consumer. However, some individuals may have natural allergic responses to one or more of the ingredients, just as some people are allergic to pollen or penicillin. These allergic responses to Protandim generally appear as gastrointestinal disturbances (i.e., stomach ache, diarrhea, vomiting) or sometimes as a headache or rash on the hands or feet. The symptoms typically disappear if Protandim is discontinued. If you are experiencing any adverse reaction, discontinue use of the product.


Nationally recognized anti-aging expert Dr. Joe McCord, the scientist behind Protandim, explains, “Researchers and scientists agree that aging is the result of cellular deterioration caused by free radicals, which are rogue molecules. It is impossible to avoid free radicals because the food you eat and the air you breathe, as well as stress or even vigorous exercise, can stimulate cells to produce destructive free radicals in staggering numbers. With each year, a person’s body becomes less effective at fighting free radicals. A person’s body fights free radicals by producing its own antioxidant enzymes. But as we grow older, our bodies produce more free radicals and fewer of these antioxidant enzymes to fight the battle of aging. That’s where Protandim plays a critical role. Protandim boosts the body’s own production of antioxidant enzymes at the cellular level with enough neutralizing capacity to eliminate the age-related increase in free radical damage.”

Protandim’s actions result from its ability to activate the transcription factor known as Nrf2. Protandim contains five ingredients that are known to scientists as Nrf2 activators. Nrf2 is a protein messenger contained in every cell of the body that sends information to the cell’s DNA.

When Nrf2 is activated, it enters the nucleus and it turns on several hundred of these 25,000 genes. And the genes that it turns on, or turns up, are known collectively as “survival genes.” What is a survival gene? These genes enable cells to survive in the face of several different kinds of stress, especially oxidative stress, which occurs when free radicals and other oxidants overwhelm the body’s natural antioxidant enzymes.

So, Protandim, as a Nrf2 activator, activates survival genes, such as antioxidant genes that keep us safe from free radicals and oxidants.

Protandim is among the very first of the products that are appearing and will appear, as Nrf2 activators.

Many people mistakenly believe their antioxidant needs are fulfilled by eating blueberries, drinking expensive “miracle juices” and applying antioxidant facial creams. What they don’t realize is that their daily antioxidant needs cannot be fulfilled by consuming any amount of blueberries, dark chocolate or red wine. Effective antioxidant protection absolutely requires the adequate production of the body’s own antioxidant enzymes.

Protandim contains a compound based upon six United States’ patents, 1 Australia patent, 1 China patent and has been proven to protect against oxidative stress.

Protandim is different from other antioxidant supplements in the way it works. Instead of providing the body with additional dietary antioxidants (regular supplements fall into this category and are commonly called consumable or “direct” antioxidants), Protandim works from within your body, to help fight free radicals and protect against oxidative stress. This is why Protandim is different than any other antioxidant on the market today; your body is actually producing the antioxidant power.


Protandim is the only supplement clinically proven (in a peer-reviewed, human clinical study) to reduce oxidative stress in humans by an average of 40 percent in 30 days. Protandim is protected by U.S. patents and is the subject of a number of peer-reviewed clinical studies. This patented antioxidant therapy is many times more powerful than red wine, oranges, blueberries, juices or other popular antioxidant supplements. Protandim works by increasing the body’s natural antioxidant protection at the cellular level by inducing the protein Nrf2 to trigger cells to produce naturally occurring protective antioxidant enzymes such as superoxide dismutase (SOD), catalase and the enzymes involved in glutathione synthesis and metabolism.